1. Why do you want to work here?
(This question implicitly includes, "Why do you want to leave where you are?" if you're currently employed.)
This question is an open opportunity to show you've done some research on the company where you're interviewing. All companies and interviewers are flattered when the interviewee knows who they are, knows what games they make, and wants to be a part of their experience. Do your homework and put on a good show!
Don't say things like, "I need a job," or "I need to move to Sacramento." Instead, pick a few things that are germane to the company in question. The more specific your reasons are tied to the company, the better. "I want to work on FPS shooters" isn't as good an answer as "I want to work on Game Franchise X because I played the first two games and still see potential for future growth of the product." It's sycophantic, yes, but interviewers are as prone to flattery as anyone else -- although don't give that as your only reason.