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I have been working at Howard Hughes Medical Institute full-time (More than 3 years)
Incredibly rewarding job doing basic research to transform medicine. The institute takes care of it's employees and HR is friendly and helpful. The benefits are great and postdoc pay (while not great) is still above average.
Extremely challenging to obtain a faculty position that is funded through HHMI :-(
Advice to Management
I wish that HHMI continued their independent postdoc fellowships since my current position is tethered to an HHMI lab. Independent fellowships would be better, even if they are still required to be administered through a HHMI host lab.