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I worked at Premier Research full-time
Premier is a great company full with energy. There are several offices throughout the world, and it does seem like the culture could be segmented from office to office, however the Boston (Quincy) office is great. Lots of flexibility with work-life balance. Benefits are very strong, PTO is generous. Very little micromanagement. Depending on the project you can derive a good sense of purpose from your work.
Work is entirely client based, and of course clients can be demanding and unaware making direct requests of employees.