Shionogi Inc.

Takayuki Yoshioka, Ph.D., President and Chief Executive Officer

Dr. Takayuki Yoshioka joined Shionogi in 1990 in Osaka, Japan and was responsible for the company’s pharmaceutical research in oncology. In his nearly 30 year tenure with Shionogi, Dr. Yoshioka has led the organization in multiple capacities including global development, global quality assurance, pharmacovigilence, and regulatory management. In his most recent role, Dr. Yoshioka served as Senior Executive Officer and Senior Vice President for the Supply Chain Management division. In that role, he was responsible for the worldwide management of Shionogi’s global supply including, procurement for manufacturing, manufacturing strategy and import/export oversight. Dr. Yoshioka also served as Chair of both the global supply, quality, manufacturer and CMC committee and the global sales and operations committee.

Prior to joining Shionogi, Dr. Yoshioka gained accolades as a visiting scientist in the Virology Laboratory with the American Red Cross and was a visiting fellow in the Laboratory of Molecular Virology of the National Institutes of Health, National Cancer Institute. Dr. Yoshioka holds his Ph.D. from the Osaka University Medical School and a Master's Degree from the University of Tsukuba Medical School.

Tadashi Hara, Executive Vice President and Chief Financial Officer

Mr. Hara joined Shionogi Inc. in July 2010, as Executive Vice President and Chief Financial Officer.

Mr. Hara originally joined Shionogi & Co., Ltd. based in Japan in 1995 and since that time has held a variety of positions with growing responsibilities in commercial, financial planning & analysis, accounting, taxes, treasury, internal controls, business development support, and other corporate functions at the Shionogi group companies on a global basis. Mr. Hara began his career with Shionogi as a sales representative in Japan, then moved to the U.S. in 2006 to serve as Director of Accounting and Finance at Shionogi USA Inc. where he was responsible for a broad spectrum of financial functions and various administrative roles. During his time with Shionogi USA Inc., he also played a key global role to liaise between Japan and the U.S., supporting R&D and business functions. Mr. Hara also served as director of the board and held senior leadership roles for other Shionogi group entities.

Mr. Hara received a bachelor’s degree in Psychology from Waseda University in Japan. He is a Certified Public Accountant.

Gary Dickinson, Executive Vice President, Chief Transformation Officer and Human Resources Officer

Gary Dickinson joined Shionogi Inc. in October 2011 and leads Shionogi’s Human Resources function in the U.S.

Prior to joining Shionogi Inc., Gary had over 25 years of Senior HR experience gained in large corporate companies such as Bristol Myers Squibb and American Express plus valuable experience gained in helping build several successful mid-size companies such as The Medicines Company. Gary has also had CEO experience at Universal WorldEvents, a pharmaceutical meeting and event planning company. His international and broad generalist HR management experience in the Consumer and Pharma sides of the Life Sciences industry give him a unique background to have a significant influence at Shionogi Inc.

Mr. Dickinson holds a B.A. Hons. Degree in Sociology from The University of Sheffield in the U.K. Gary also holds an Executive Certificate in Leadership Coaching from Georgetown University and is qualified as a Professional Certified Coach by the International Coach Federation.

Joseph M. Spagnardi, Executive Vice President, Legal and Compliance

Mr. Spagnardi joined Shionogi Inc. in June 2013 and is currently Executive Vice President overseeing Legal and Compliance. In this role, Joe serves as the General Counsel, Chief Compliance Officer, Corporate Secretary of the Company, and is responsible for all legal and compliance matters.

Joe has extensive legal experience in both private practice and senior corporate legal roles, most of which has been in the pharmaceutical industry. In his previous position, Joe served as the Senior Vice President, General Counsel and Secretary of Inspire Pharmaceuticals, Inc., a publicly-traded pharmaceutical company, acquired by Merck & Co., Inc. Prior to that, Joe held senior legal positions at GlaxoSmithKline where he served as Assistant General Counsel – R&D Operations, and Glaxo Wellcome, where he served as a Senior Counsel focusing on transactional matters. Joe started his legal career at the law firm of Winthrop, Stimson, Putnam and Roberts, now Pillsbury Winthrop Shaw Pittman in New York, specializing in corporate transactions.

Joe holds a J.D. with Honors from the University of North Carolina School of Law and a B.S. in Business Administration (Finance) from the University of Delaware. He has been admitted to the Bar in the State of New York since 1990.