Pros

Leading research institution Many opportunities for collaboration Many core resources Frequent seminars, etc to meet leading scholars A career development program is available to postdocs

Cons

As elsewhere, postdoctoral salaries are significantly lower than industry jobs, etc Your success highly depends on the research group that you join You have to be a good scientist, and there is a luck element in the research you do as well As elsewhere, postdoc period is a ticking clock, and there is a lot of stress associated with making steady progress with research/publication There may be some specific cons about VUMC that others would notice, but they don't really come to mind, I think VUMC/Vanderbilt are comparable to many other leading research institutions