During the Node.js interview, the interviewer began by asking me about my experience with JavaScript and server-side development. They then delved into my understanding of Node.js concepts like event-driven programming and asynchronous programming. I was asked to explain the use of modules and package management in Node.js, as well as my familiarity with popular frameworks like Express. They also inquired about my experience working with libraries like Axios for making HTTP requests and Mongoose for interacting with MongoDB. Throughout the interview, I was given coding exercises to demonstrate my problem-solving skills and ability to write clean, efficient code. Overall, the interview was challenging yet insightful, providing an opportunity to showcase my Node.js expertise and passion for server-side development.