Check out your Company Bowl for anonymous work chats.
#ImagingMassCytometry allows the detection of protein targets and provides general architectural details on #FFPE sections of both normal and cancerous tissues. The resolution of IMC permits visualization of proteins in the membranous, cytoplasmic and nuclear cell compartments. The benefit over traditional IHC techniques is the ability to #multiplex over 50 markers in a single experiment, enabling high-content analysis of human tissue with fewer tissue samples required. Check out this #whitepaper discussing the equivalence of IMC and #immunofluorescence on FFPE tissue sections, including a comparison table of different #immunostaining methods: https://lnkd.in/gPNvHd3
We are excited about this panel discussion on the future of mass cytometry in clinical research and therapeutic development with Erika J. Crosby, PhD, Holden Maecker, PhD and Yann Abraham, PhD. Join us on May 25! https://lnkd.in/gCbh6-A
Dr. Chris Tape, from Cancer Research UK (CRUK), will be joining us at the 18th CIMT Annual Meeting on Monday 10 May, 11:00 BST/12:00 CEST. Dr. Tape will be discussing, Single-cell signaling analysis of tumor microenvironment organoids. There will be time for your questions after the talk. Please note, there is a fee to register for this conference. We hope you can join us! Link to register: https://lnkd.in/dWtAdKk
Scientists at Sapienza Università di Roma have made more headway in determining outcomes from #SARSCoV2 infection. The team looked at thyroid function, its association with SARS-CoV-2 severity, and clinical relevance of Low T3 syndrome. Using high-dimensional #singlecell analysis by #masscytometry, multiplex cytokine assay and #geneexpression profiling in PBMC, the team performed gene signature analysis and #immuneprofiling in #COVID19 patients. Thyroid function alterations appear to be frequently observed in the acute phase of COVID-19. Low FT3 serum values correlate with disease severity and an increase in the serum levels of markers for coagulation, inflammation and tissue damages, and so could be considered as a prognostic marker of COVID-19. https://lnkd.in/gbiZtYN
An understanding of the molecular and cellular basis of #COVID19 #pathogenesis is paramount to the development of effective therapies and vaccines to help control the pandemic. We are thrilled to have Andrea Cossarizza, MD, PhD, present a #systemsbiology approach to COVID-19 research and recent immunological advances in the fight against SARS-CoV-2. Save your seat here: https://lnkd.in/gdv487z
Mark your calendars! Drs. Hartland Jackson and Cynthia Guidos will overview their use of #masscytometry to study the tissue architecture and immune landscapes in human and mouse #breastcancer. They will then answer your questions about how to use this technology in your projects. We hope you can join us! See more here: https://lnkd.in/gGW5M2d
The tumor microenvironment plays a major role in high-grade serous ovarian cancer patient survival. To investigate how different cells interact to influence HGSC patients’ survival, a collaborative team developed a pipeline that combines #imagingmasscytometry, location-specific #transcriptomics, and deep learning to identify the distribution of various stromal, tumor and immune cells as well as their spatial relationship. Here's the #publication: https://lnkd.in/gTjtYgk HOUSTON METHODIST HOSPITAL and affiliate Weill Cornell Medicine, MD Anderson Cancer Center and other collaborators
#Breastcancer #genomics is known to play a role in drug response and resistance, but non-genomic tumor evolution can also generate phenotypic heterogeneity. Researchers at the Cancer Research UK (CRUK) used #masscytometry for high-throughput multi-parametric analysis of cellular heterogeneity and oncogenic signaling states in a biobank of patient-derived tumor xenograft models. The team developed a 33-marker #CyTOF panel, selected to profile markers relevant to breast cancer and to separate cells of murine and human origin. #Singlecell profiling revealed drug-induced cellular phenotypic dynamics and that pre-treatment cellular phenotypic composition is a determinant of anticancer therapy response. “Mass cytometry has provided unprecedented insights into normal tissue function and tumour biology, including the malignant cell-autonomous compartment and/or the tumour microenvironment,” the #publication states - https://lnkd.in/gvEWSuw
We are delighted to welcome Dr. Chotima Böttcher for a live webinar on Monday 26 April 07:30 PT | 10:30 ET | 15:30 BST | 16:30 CEST . Organized by Dr. Jennifer Dowling (FutureNeuro Centre, Royal College of Surgeons Ireland) for Neuro Science Ireland and the Irish Society of Immunology. Register now: https://lnkd.in/gyKyn84 In this #webinar: - An introduction to both suspension #masscytometry and #ImagingMassCytometry by Roberto Spada, Senior Market Development Manager, Fluidigm - A review of #CyTOF technology for #immunology, #neurology, and #neuroimmunology research by Dr. Chotima Böttcher - How Dr. Böttcher has used the technology in multiple sclerosis research. If you cannot attend the live broadcast, your registration will allow you to view an on-demand recording after the event. We look forward to seeing you there!
Join us for an open panel discussion with leading research pathologists on the challenges of profiling the tissue microenvironment down to the #singlecell level. Learn how the new cloud-based AccuLift™ Laser Capture Microdissection System digital pathology research solution is designed to offer novel spatial insights, provide high-quality RNA and transform your day-to-day workflow. Register now: https://lnkd.in/gJhRxGC And don’t forget to vote! The AccuLift™ Laser Capture Microdissection System has been nominated for the Scientists' Choice Awards® 2021 in the Best New Life Sciences Product of 2020 category. Help it win by voting here: https://lnkd.in/gFvP4yd
