Pros
Great benefits. Competetive Salary. Really nice coworkers. Good equipment for home-based employees. In terms of what a lot of the big CROs offer, I think ICON is probably the best in terms of benefits. I haven't found anyone that can beat it.
Cons
Typically CRO cons - lots of travel, tough expectations, demanding sponsors. No cell phone or phone stipen for travelling CRAs makes life difficult. I think your experience here really depends on the study/sponsor teams. I work with two different teams and find one to be a pleasant experience and the other has me in tears of frustration. They are also transitioning from a mid-size to large-size CRO in a tough economy and I know at least the CRAs are feeling that squeeze. But it's not unreasonable compared to other CROs. The technology, especially CTMS, is really not efficient or modern. Big improvements to be made here. Difficult to get promoted. Doesn't really have a culture.